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Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors: Case Report

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Kasashima S, Minato H, Kobayashi M, Ueda Y, Oda Y, Hashimoto S, Inoue M. Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors. APMIS 2007;115:00–00

Alveolar soft part sarcoma (ASPS) is a rare tumor of uncertain histogenesis, mainly localized in the extremities. ASPS originating in the uterine corpus is quite rare; only eight such cases have been reported in the literature. We here present another case of ASPS found in the endometrium in a 50-year-old woman. Metastatic malignant tumor, including ASPS from other organs, was excluded by physical examination and imaging modalities. Thallium 201 was only localized in the uterus. The tumor showed characteristic histological features of ASPS: alveolar architecture with fibrovascular septa and abundant eosinophilic granular cytoplasm with periodic acid-Schiff-positive crystalline material. Diffuse nuclear immunoreactivity for TFE3, a marker recently reported to be specific for ASPS, further supported the diagnosis of ASPS. Interestingly, this tumor was negative for myogenic markers, but positive for CD10, progesterone receptor, and estrogen receptor. These immunohistochemical results and the tumor location suggest a possible link between endometrial stromal cells and the development of this tumor.
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Keywords: Alveolar soft part sarcoma; CD10; endometrium; estrogen receptor; progesterone receptor

Document Type: Case Report

Affiliations: 1: Pathology Section, Kanazawa University Hospital, Ishikawa, 2: Kanazawa Municipal Hospital, Pathology, 3: Department of Pathophysiological and Experimental Pathology, Kanazawa Medical University, 4: Pathology Laboratory, ALP Company, 5: Kanazawa Municipal Hospital, Gynecology, and 6: Department of Gynecology, School of Medicine, Kanazawa University, Ishikawa, Japan

Publication date: 2007-07-01

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