If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

LAMPs and ABH histo-blood group antigens in granulation tissue

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Sarafian VS, Dikov D I. LAMPs and ABH histo-blood group antigens in granulation tissue. APMIS 2007;115:701–6.

Endothelial cells are major participants in angiogenic processes accompanying wound repair. The functions of ABH histo-blood group antigens (HBGAs) and lysosome-associated membrane proteins LAMP-1 and LAMP-2 in endothelial cells of granulation tissue are currently unkown. Here we hypothesize that HBGAs and LAMPs enrich the phenotypic characteristics of endothelial cells and might be implicated in the plasticity of granulation tissue. Immunohistochemistry revealed permanent expression of HBGAs in the cytoplasm of endothelial cells of all sprouting capillaries regardless of the organ examined. A modulation in both the localization and the intensity of the signal for LAMPs was observed. Interestingly, LAMP-1 showed a more intensive staining compared to LAMP-2. LAMP-1 was found in the cytoplasm, as well as on plasma membranes of endothelial cells. We present the first comparative immunohistochemical study of the expression of HBGA and LAMPs in endothelial cells of granulation tissue. Novel evidence for modulating LAMP reactivity is reported. Our results suggest that both glycoconjugates might contribute to the process of neoangiogenesis and tissue remodeling in wound healing.

Keywords: ABH histo-blood group antigens; endothelial cells; granulation tissue; lysosome-associated membrane proteins (LAMPs)

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2007.apm_576.x

Affiliations: Centre Hospitalier de Lagny-Marne-La-Vallée, Service d'Anatomie et de Cytologie Pathologiques, Lagny-sur-Marne, France

Publication date: June 1, 2007

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more