Coagulase-negative staphylococci isolated from sternal wound infections after cardiac surgery: attachment to and accumulation on sternal fixation stainless steel wires

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Abstract:

Olsson E, Friberg Ö, Venizelos N, Koskela A, Källman J, Söderquist B. Coagulase-negative staphylococci isolated from sternal wound infections after cardiac surgery: attachment to and accumulation on sternal fixation stainless steel wires. APMIS 2007;115:142–51.

Sternal wound infection (SWI) is a serious complication after cardiac surgery. Coagulase-negative staphylococci (CoNS) have been found to be the most common pathogen involved in this postoperative infection related to implanted foreign materials, i.e. sternal fixation wires made from stainless steel. In this study a rapid and simple assay was developed for studying attachment and accumulation of CoNS on stainless steel wires in vitro using [3H] thymidine. The method showed a potential to detect differences in the dynamics of the adherence patterns among various CoNS isolates. However, no differences in attachment and accumulation were found between isolates causing deep SWI after cardiac surgery and contaminant isolates. In addition, there were no differences in the distribution of the ica operon between the two groups, as determined by polymerase chain reaction (PCR). Nevertheless, the ability to produce biofilm was found to be present significantly more frequently among SWI isolates than among contaminants.

Keywords: Bacterial adhesion; biofilm; in vitro test; stainless steel; staphylococcal infections

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2007.apm_559.x

Affiliations: 1: Cardiothoracic Surgery, Örebro University Hospital, 2: Department of Clinical Medicine, Örebro University, Departments of 3: Clinical Research Centre, Örebro University Hospital, and Departments of 4: Infectious Diseases, and

Publication date: February 1, 2007

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