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Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology: Case report

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Madsen CW, Hasselby JP, Larsen LG. Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology. Case report. APMIS 2006;114:574–9.

We report a case of primary peritoneal carcinoma with trophoblastic morphology in a 78-year-old woman, diagnosed by histological and immunohistochemical analysis of surgically resected specimens, including the omentum and part of the small bowel. Microscopically, the resected specimens showed diffuse infiltration of a poorly differentiated tumor. Numerous large, often multinucleated cells were seen, and mitotic figures were frequent. Immunohistochemical staining showed a positive reaction for most cytokeratins, EP4, EMA, CA-125, Glut1, WT1, β-hCG and PLAP. We reached a diagnosis of primary peritoneal carcinoma with trophoblastic morphology. To our knowledge this morphology of a primary peritoneal carcinoma has not been described previously.
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Keywords: Peritoneum; carcinoma; human chorionic gonadotropin; immunohistochemistry; trophoblastic

Document Type: Research Article

Affiliations: Department of Pathology, Naestved Hospital, Denmark

Publication date: 2006-08-01

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