Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology: Case report
Authors: MADSEN, CHARLOTTE WINTHER; HASSELBY, JANE PREUSS; LARSEN, LISE GRUPE
Source: Apmis, Volume 114, Numbers 7-8, August 2006 , pp. 574-579(6)
Abstract:Madsen CW, Hasselby JP, Larsen LG. Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology. Case report. APMIS 2006;114:574–9.
We report a case of primary peritoneal carcinoma with trophoblastic morphology in a 78-year-old woman, diagnosed by histological and immunohistochemical analysis of surgically resected specimens, including the omentum and part of the small bowel. Microscopically, the resected specimens showed diffuse infiltration of a poorly differentiated tumor. Numerous large, often multinucleated cells were seen, and mitotic figures were frequent. Immunohistochemical staining showed a positive reaction for most cytokeratins, EP4, EMA, CA-125, Glut1, WT1, β-hCG and PLAP. We reached a diagnosis of primary peritoneal carcinoma with trophoblastic morphology. To our knowledge this morphology of a primary peritoneal carcinoma has not been described previously.
Document Type: Research Article
Affiliations: Department of Pathology, Naestved Hospital, Denmark
Publication date: August 1, 2006