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Pin1 gene mutation is a rare event in gastric cancer

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Abstract:

Kim CJ, Song JH, Cho YG, Chae HS, Nam SW, Yoo NJ, Lee JY, Park WS. Pin1 gene mutation is a rare event in gastric cancer. APMIS 2006;114:518–22.

The peptidyl-prolyl isomerase Pin1 is strikingly overexpressed in human cancers and is a novel regulator of β-catenin. To determine whether somatic mutation of the Pin1 gene is involved in the development and/or progression of gastric cancer, we searched for mutations of the Pin1 gene in 95 gastric cancer specimens. The effect of Pin1 on β-catenin expression was further examined in wild- and mutant-type Pin1-transfected HEK 293T cells. We found only one missense mutation that led to the substitution of alanine by aspartic acid at codon 118 of the Pin1 gene. On transfection study, the mutant Pin1 showed an increased expression of β-catenin. However, the mutation had no effect on expression of the Pin1 protein in the case with Pin1 mutation. These results suggest that Pin1 may not play a role in the development or progression of gastric cancer.

Keywords: Stomach; mutation; peptidyl-prolyl isomerase; β-catenin

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2006.apm_379.x

Affiliations: 1: Pathology and 2: Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Publication date: August 1, 2006

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