Skip to main content

Pancreatic endocrine tumor with partial acinar cell differentiation: Case report

Buy Article:

$51.00 plus tax (Refund Policy)


Minakawa K, Oka K, Nihei T, Sando N, Oikawa H, Toda J, Hosokawa Y, Matsumoto T, Yanagisawa A. Pancreatic endocrine tumor with partial acinar cell differentiation. APMIS 2006;114:720–5.

We examined a 70-year-old woman in whom a pancreatic endocrine tumor with partial acinar cell differentiation had been diagnosed. She had neither endocrine nor exocrine symptoms. The tumor was located in the pancreatic tail and measured 12.5×9.5×8 cm. It had a capsule, was composed of multiple adhesion nodules, and was elastically soft, medullary, and yellowish white. The neoplastic cells had large, irregular, oval nuclei; prominent eosinophilic nucleoli; and abundant eosinophilic cytoplasm with many fine granules. The cells had proliferated in islet-like solid medullary, trabecular, acinar, and papillary patterns. Most neoplastic cells were strongly positive for synaptophysin. 10 to 25% of the neoplastic cells were positive for α1-antitrypsin. Neuroendocrine and zymogen granules were simultaneously observed in the cytoplasm of the same neoplastic cells at the ultrastructural level. The tumor may be considered an amphicrine tumor.

Keywords: Pancreatic endocrine tumor; acinar cell differentiation; electron microscopy; neuroendocrine granule; zymogen granule

Document Type: Research Article


Affiliations: 1: Internal Medicine, 2: Surgery, and 3: Radiology, Mito Saiseikai General Hospital, Mito, Ibaraki, 4: First Department of Pathology, Juntendo University, School of Medicine, Tokyo, and 5: Department of Pathology, Prefecture Medical Graduate School of Medical Sciences, Kyoto, Japan

Publication date: 2006-10-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more