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Pancreatic endocrine tumor with partial acinar cell differentiation: Case report

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Minakawa K, Oka K, Nihei T, Sando N, Oikawa H, Toda J, Hosokawa Y, Matsumoto T, Yanagisawa A. Pancreatic endocrine tumor with partial acinar cell differentiation. APMIS 2006;114:720–5.

We examined a 70-year-old woman in whom a pancreatic endocrine tumor with partial acinar cell differentiation had been diagnosed. She had neither endocrine nor exocrine symptoms. The tumor was located in the pancreatic tail and measured 12.5×9.5×8 cm. It had a capsule, was composed of multiple adhesion nodules, and was elastically soft, medullary, and yellowish white. The neoplastic cells had large, irregular, oval nuclei; prominent eosinophilic nucleoli; and abundant eosinophilic cytoplasm with many fine granules. The cells had proliferated in islet-like solid medullary, trabecular, acinar, and papillary patterns. Most neoplastic cells were strongly positive for synaptophysin. 10 to 25% of the neoplastic cells were positive for α1-antitrypsin. Neuroendocrine and zymogen granules were simultaneously observed in the cytoplasm of the same neoplastic cells at the ultrastructural level. The tumor may be considered an amphicrine tumor.
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Keywords: Pancreatic endocrine tumor; acinar cell differentiation; electron microscopy; neuroendocrine granule; zymogen granule

Document Type: Research Article

Affiliations: 1: Internal Medicine, 2: Surgery, and 3: Radiology, Mito Saiseikai General Hospital, Mito, Ibaraki, 4: First Department of Pathology, Juntendo University, School of Medicine, Tokyo, and 5: Department of Pathology, Prefecture Medical Graduate School of Medical Sciences, Kyoto, Japan

Publication date: 2006-10-01

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