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Pulmonary cryptosporidiosis: role of COX2 and NF-kB

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Abstract:

Asaad NY, Sadek GS. Pulmonary cryptosporidiosis: role of COX2 and NF-kB. APMIS 2006;114:682–9.

In the present study we investigated whether the pathological changes induced by Cryptosporidium in the lungs are mediated through the activation of COX-2, and whether the pathway employed for this activation involves NF-kB. 70 albino rats were submitted for this work. They were categorized into 3 groups: 30 immunocompetent (IC) rats infected with Cryptosporidium oocysts, 30 immunosuppressed (IS) rats infected with Cryptosporidium oocysts, and 10 IC, non-infected rats. Immunohistochemical expression of COX2 and NF-kB in lung tissues of the rats was examined. 43.3% of IC rats showed chronic pneumonia and fibrosis, 40% COX2 positivity, and 36.67% NF-kB positivity. 96.7% of IS rats showed chronic pneumonia and fibrosis, 56.7% non-caseating granuloma with Cryptosporidium oocysts, and 66.7% positivity for both COX2 and NF-kB. Density of inflammatory infiltration was statistically correlated with quickscore of both COX2 and NF-kB in both IC and IS groups. An association between quickscores of COX2 and NF-kB was found in our studied material. These data could demonstrate that Cryptosporidium infection induces upregulation of COX2 possibly through the NF-kB pathway, which suggests the events that contribute to the pathogenesis of Cryptosporidium. These findings could indicate potential therapeutic pharmacological target-mediating treatment of lesions caused by Cryptosporidium.

Keywords: COX2; Cryptosporidium; NF-kB

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2006.apm_499.x

Affiliations: Parasitology, Faculty of Medicine, Menoufiya University, Shebin El-kom, Egypt

Publication date: October 1, 2006

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