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How to outwit the enemy: dendritic cells face Salmonella: Review article

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Biedzka-Sarek M, Skurnik M. How to outwit the enemy: dendritic cells face Salmonella. APMIS 2006;114:589–600.

Salmonella enterica serovar Typhi causes typhoid fever, a serious life-threatening systemic infection. In mice, a similar disease is caused by Salmonella enterica serovar Typhimurium. During typhoid fever, soon after attachment to the mucosal surface of the gut, bacteria come into contact with the dendritic cells (DCs). The ability to sample antigens, process and present them to naıÐve and mature T cells, in the context of major histocompatibility complex molecules, makes DCs indispensable for mounting a specific and efficient immune response to invading pathogens. These bacteria, however, have evolved a number of mechanisms to interfere with or subvert DC functions. This review aims to describe how Salmonella clashes with dendritic cells at different stages of infection as well as the war strategies of these two opposing sides.

Keywords: Salmonella; antigen presentation; dendritic cells; review

Document Type: Research Article


Publication date: September 1, 2006


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