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Preoperative CA125 as a prognostic factor in stage I epithelial ovarian cancer

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Abstract:

Petri AL, Høgdall E, Christensen IJ, Kjaer SK, Blaakær J, Høgdall CK. Preoperative CA125 as a prognostic factor in stage I epithelial ovarian cancer. APMIS 2006;114:359–63.

The purpose of the present study was to evaluate preoperative CA125 as a prognostic factor in stage I epithelial ovarian cancer (EOC). Preoperative serum CA125 levels from 118 women with FIGO (International Federation of Gynaecology and Obstetrics) stage I EOC were analysed and the prognostic value was evaluated and compared with other prognostic factors (age, grade, substages, histologic type). By the Kaplan-Meier estimate we demonstrated that patients with stage I EOC and preoperative serum CA125 levels <65 U/mL had a significantly longer survival compared to stage I EOC patients with preoperative serum CA125≥65 U/mL (p=0.01). The results from the present study may be useful for decision making respecting postoperative chemotherapy in stage I EOC patients. Serum CA125 levels might therefore be included as a prognostic factor in future clinical trials of stage I EOC.

Keywords: Preoperative CA125; ovarian cancer stage; prognostic factor

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2006.apm_397.x

Affiliations: 1: Institute of Cancer Epidemiology, Danish Cancer Society, 2: Department of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen University Hospital, Copenhagen, and 3: Department of Gynaecology and Obstetrics, Aarhus University Hospital Skejby, Aarhus, Denmark 4: Department of Gynaecology and Obstetrics, Rigshospitalet, Copenhagen University Hospital,

Publication date: May 1, 2006

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