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Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma

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Abstract:

Soini Y, Kallio JP, Hirvikoski P, Helin H, Kellokumpu-Lehtinen P, Kang SW, Tammela TLJ, Peltoniemi M, Martikainen PM, Kinnula VL. Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma. APMIS 2006;114:329–37.

Peroxiredoxins (Prxs) 1–6 were assessed in 138 renal cell carcinomas (RCC) using immunohistochemistry and selected samples by Western blotting analysis. Oxidative/nitrosative damage was evaluated using nitrotyrosine immunoreactivity. The expressions of Prxs were correlated with tumor grade and survival and nitrotyrosine reactivity. Non-malignant kidney tubular cells showed positivity with variable intensity for all six Prxs. In RCCs, most cases were positive for Prxs 1 and 2, while only 15–20% of tumors showed expression for Prxs 3 and 4. Prx 2 was associated with tumors of a lower grade (p=0.009) and with a lower frequency of distant metastases (p=0.046). Patients with tumors expressing Prx2 had better prognosis (p=0.027). Instead, nitrotyrosine was significantly associated with high grade tumors (p=0.001). Compared with the non-malignant kidney tubular cells, low Prx expression in the tumor cells can make them more susceptible to oxidative damage. Prx 2 was more abundantly expressed in low grade tumors, suggesting that this protein could play a role in preventing the development of oxidative damage, which in turn can lead to the activation of pathways leading to aggressive tumors.

Keywords: Oxidative damage; cancer; kidney

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2006.apm_315.x

Affiliations: 1: Department of Urology, Tampere University Hospital, Tampere, 2: Department of Pathology, University of Oulu, 3: HUSLAB, Division of Pathology, Helsinki University Central Hospital, Helsinki, 4: Department of Oncology, Tampere University Hospital and Medical School, University of Tampere, Finland 5: The Center for Cell Signalling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul, Korea 6: Department of Urology, Tampere University Hospital, and Medical School, University of Tampere, Tampere, 7: Department of Biochemistry, University of Oulu, Oulu, 8: Department of Pathology, Tampere University Hospital, Tampere, 9: Department of Medicine, Division of Pulmonary Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Publication date: May 1, 2006

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