Skip to main content

Otomicroscopic findings and systemic interleukin-6 levels in relation to etiologic agent during experimental acute otitis media

Buy Article:

$43.00 plus tax (Refund Policy)

Foglé-Hansson M, White P, Hermansson A, Melhus Å. Otomicroscopic findings and systemic interleukin-6 levels in relation to etiologic agent during experimental acute otitis media. APMIS 2006;114:285–91.

The aim of the present study was to explore whether it was possible to differentiate the clinical course and the otomicroscopic appearance of acute otitis media (AOM) caused by common otitis pathogens in an animal model. Systemic interleukin (IL)-6 levels as early markers for bacterial AOM were also studied. Four groups of rats were inoculated with either Streptococcus pneumoniae, Streptococcus pyogenes, non-typeable Haemophilus influenzae or Moraxella catarrhalis. The animals were monitored by otomicroscopy, photos of the tympanic membrane, cultures and IL-6 detection in serum the following 4 days. The gram-positive S. pneumoniae and S. pyogenes induced severe AOM with opaque effusion behind the tympanic membrane, pronounced dilation of the vessels and spontaneous perforations. The gram-negative H. influenzae and M. catarrhalis induced a less severe infection with cloudy, sometimes foamy effusion, and no spontaneous perforations. With the otomicroscopic findings it was possible to distinguish between infections induced by gram-positive bacteria and gram-negative bacteria. Detection of interleukin-6 in serum appeared to be of limited use for all infections except the pneumococcal AOM, but this needs to be further investigated.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Acute otitis media; IL-6; animal model; diagnosis; otomicroscopy

Document Type: Research Article

Affiliations: 1: Department of Oto-Rhino-Laryngology, Lund University Hospital, Lund, and 2: Department of Medical Sciences/Division of Bacteriology, Uppsala University Hospital, Uppsala, Sweden

Publication date: 2006-04-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more