Skip to main content

Post-transplant reactivation of hepatitis C virus: lymphocyte infiltration and the expression of adhesion molecules and their ligands in liver allografts

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Lipson K, Lappalainen M, Höckerstedt K, Lautenschlager I. Post-transplant reactivation of Hepatitis C virus: lymphocyte infiltration and the expression of adhesion molecules and their ligands in liver allografts. APMIS 2006;114:247–54.

Hepatitis C virus (HCV) recurrence after liver transplantation has been associated with chronic rejection. Biopsies from 10 patients with post-transplant HCV were examined for expression of adhesion molecules ICAM-1, VCAM-1, and ELAM-1, number of lymphocytes positive for their ligands LFA-1, VLA-4, and SLeX, and activation markers MHC class II antigens and IL2-R by immunohistochemistry. The phenotypes of the graft-infiltrating lymphocytes were determined. Results were compared to those for patients with normal graft function or rejection. Five recipients with HCV reactivation and one with de novo HCV had a biopsy available showing induction of ICAM-1 in sinusoidal endothelium (p<0.05) and hepatocytes (p<0.01), and Class II antigens in hepatocytes (p<0.01), compared to normal controls. Lymphocytes in the graft infiltrate expressed LFA-1, VLA-4, and Class II antigens, but IL2-R was not significantly expressed. CD3+, CD4+, and CD8+ cells were observed. In our study, HCV recurrence was not associated with acute or chronic rejection, and the inflammation was due to the viral infection.

Keywords: Adhesion molecules; hepatitis C virus infection; liver transplantation

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0463.2006.apm_130.x

Affiliations: 1: and Surgery 2: , Transplantation and Liver Surgery Unit, Helsinki University Hospital and University of Helsinki Transplant Unit Research Laboratory, Finland

Publication date: 2006-04-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more