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Prevalence, susceptibility profile and proteinase production of yeasts causing vulvovaginitis in Turkish women

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Abstract:

Ozcan SK, Budak F, Yucesoy G, Susever S, Willke A. Prevalence, susceptibility profile and proteinase production of yeasts causing vulvovaginitis in Turkish women. APMIS 2006;114:139–45.

In this study the prevalence of vulvovaginal candidiasis (VVC), antifungal susceptibility and proteinase production of isolated Candida species were investigated. Vaginal swabs were collected from symptomatic women with vulvovaginitis attending the Obstetrics and Gynecology Clinic of Kocaeli University, Turkey. The relation between risk factors, such as pregnancy, diabetes mellitus, antibiotic and corticosteroid use, history of sexually transmitted diseases and contraceptive methods, was recorded. Candida spp. were identified by conventional methods, then evaluated for proteinase secretion in a medium containing casein. Antifungal susceptibility was determined according to the NCCLS microdilution method. The prevalence of women with vulvovaginitis was 35.7% (170/6080) and 16% (28/170) of them were diagnosed as VVC. Candida albicans was the dominant species: 21 (75%), followed by 4 C. glabrata (14%), 2 C. tropicalis (7%), and one C. krusei (3.5%). All isolates were susceptible to fluconazole, itraconazole and amphotericin B, except one C. krusei, one C. glabrata and one C. albicans that were resistant to fluconazole. Proteinase production was determined in 19 (90.5%) C. albicans and in all C. tropicalis isolates. Proteinase activity was not associated with antifungal resistance. No association was found between risk factors and VVC.

Keywords: Vulvovaginal candidiasis; antifungal susceptibility; proteinase; risk factors

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2006.apm_360.x

Affiliations: 1: Microbiology and 2: Obstetrics and Gynecology, Medical Faculty, Kocaeli University, 3: Department of Microbiology, Istanbul Medical Faculty, Istanbul University, Istanbul, and 4: Department of Infectious Diseases, Medical Faculty, Kocaeli University, Kocaeli, Turkey

Publication date: February 1, 2006

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