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The influence of adhesive and invasive properties of Staphylococcus aureus defective in fibronectin-binding proteins on secretion of interleukin-6 by human endothelial cells

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Abstract:

Söderquist B, Alriksson I, Källman J, Kihlström E. The influence of adhesive and invasive properties of Staphylococcus aureus defective in fibronectin-binding proteins on secretion of interleukin-6 by human endothelial cells. APMIS 2006;114:112–6.

Fibronectin-binding proteins (FnBP) are surface adhesins of Staphylococcus aureus documented to be virulence attributes in, for example, endovascular infections. By using mutants of S. aureus defective in the FnBPA and B genes we have investigated whether these adhesins affect cytokine expression in human umbilical vein endothelial cells (HUVEC). S. aureus expressing FnBPA and B adhered to and were internalized into HUVEC to a greater extent compared to mutants defective in expression of FnBP. Production and release of IL-6 was higher from endothelial cells infected with the parent FnBP-expressing strain compared to the FnBP-defective mutants. These results indicate that adhesion to and invasion of S. aureus into endothelial cells are important regulators of cytokine expression.

Keywords: HUVEC; IL-6; S. aureus; adhesion; fibronectin-binding proteins

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2006.apm_319.x

Affiliations: 1: Clinical Microbiology, University Hospital, Örebro, 2: Infectious Diseases, and 3: Division of Clinical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

Publication date: February 1, 2006

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