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Soluble haemoglobin scavenger receptor (sCD163) in patients with suspected community-acquired infections

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Abstract:

Gaïni S, Koldkjær OG, Pedersen SS, Pedersen C, Moestrup SK, Møller HJ. Soluble haemoglobin scavenger receptor (sCD163) in patients with suspected community-acquired infections. APMIS 2006;114:103–11.

The aim of our study was to evaluate soluble haemoglobin scavenger receptor (sCD163) as a molecular marker in patients with community-acquired infections. One hundred and ninety-four adult patients admitted to the Department of Internal Medicine, Odense University Hospital, with suspected community-acquired infection were included in a prospective study. Plasma and serum were sampled from all patients on day of admission and sCD163 and interleukin-6 levels were measured. Demographic data, co-morbidity, microbiological aetiology, biochemical parameters, focus of infection, severity score and mortality on day 28 were recorded. Median age was 68 (range 18–92) years. Mortality rate among infected patients on day 28 was 3.8%. sCD163 concentrations (median and range) were: 2.99 mg/l (1.22–12.65) in non-infected patients, 3.62 mg/l (1.59–74.04) (p=0.08) in infected patients without systemic inflammatory response syndrome, 3.2 mg/l (0.54–22.51) (p=0.4) in patients with sepsis, 3.63 mg/l (1.71–28.4) (p=0.01) in patients with severe sepsis, and 4.9 mg/l (2.66–28.4) (p=0.003) in patients with bacteraemia. In this cohort dominated by mild infections, a moderate elevation of sCD163 was observed only in patients with severe sepsis and/or bacteraemia. sCD163 did not discriminate between infected and non-infected patients.

Keywords: CD163; community-acquired infections; innate immunity; macrophage; sepsis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2006.apm_341.x

Affiliations: 1: Department of Clinical Biochemistry, Sønderborg Hospital, Sønderborg and departments of 2: Department of Infectious Diseases, Odense University Hospital, Odense, 3: Clinical Biochemistry, University of Aarhus and Aarhus University Hospital, Aarhus, Denmark

Publication date: February 1, 2006

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