Skip to main content

Tenascin-C expression in Merkel cell carcinoma lymph node metastasis

Buy Article:

$43.00 plus tax (Refund Policy)

Koljonen V, Böhling T, Tukiainen E, Haglund C, Jahkola T. Tenascin-C expression in Merkel cell carcinoma lymph node metastasis. APMIS 2006;114:39–42.

Expression of tenascin-C (Tn-C) has been shown to correlate with invasion and metastasis in Merkel cell carcinoma (MCC). Cytokeratin-20 (CK-20) is used in differential diagnostics of the primary tumour. The aim of this study was to demonstrate the expression of Tn-C in MCC lymph node metastases. Immunohistochemical staining was performed for five metastatic lymph nodes using a monoclonal antibody against Tn-C and CK-20. All five metastatic lymph nodes expressed Tn-C. The expression concentrated around the vascular structures, invasion borders and fibrotic septae. One of the metastatic lymph nodes was strongly positive for CK-20 while the others showed a focal or negative pattern. The normal lymphoid tissue was negative for Tn-C. Tn-C detected metastatic MCC tissue within the lymph nodes undisputedly. There was a clear distinction between the metastatic and normal lymphatic tissue. Furthermore, invasion to the surrounding tissue was easily demonstrated. Contrary to previous studies, CK-20 expression seemed to fluctuate.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: CK-20; Merkel cell carcinoma; Tenascin-C; lymph node metastasis

Document Type: Research Article

Affiliations: 1: Department of Pathology, Helsinki University and HUSLAB, and 2: Department of Plastic Surgery, Helsinki University Hospital, 3: Department of Gastroenterological and General Surgery, Helsinki University Hospital, Helsinki, Finland

Publication date: 2006-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more