Inhibition of T-cell responses by CD4 on an antigen-presenting cell
Abstract:Hansen T. Inhibition of T-cell responses by CD4 on an antigen-presenting cell. APMIS 2006;114:32–8.
In addition to T-helper cells, CD4 is expressed on monocytes, macrophages and dendritic cells. To see whether CD4 molecules on antigen-presenting cells affect T-cell responses, we expressed CD4 on Raji cells, and compared positive and negative cells as stimulator cells for peripheral blood mononuclear cells in mixed lymphocyte reactions. We found that expression of CD4 on Raji had an inhibitory effect on production of IFN-γ and other cytokines.
Document Type: Research Article
Publication date: 2006-01-01