Skip to main content

Stem cells and diabetes treatment

Buy Article:

$51.00 plus tax (Refund Policy)

Madsen OD. Stem cells and diabetes treatment. APMIS 2005;113:858–75.

Diabetes mellitus types 1 and 2 are characterized by absolute versus relative lack of insulin-producing β cells, respectively. Reconstitution of a functional β-cell mass by cell therapy – using organ donor islets of Langerhans – has been demonstrated to restore euglycaemia in the absence of insulin treatment. This remarkable achievement has stimulated the search for appropriate stem cell sources from which adequate expansion and maturation of therapeutic β cells can be achieved. This recent activity is reviewed and presented with particular focus on directed differentiation from pluripotent embryonic stem cells (versus other stem/progenitor cell sources) based on knowledge from pancreatic β-cell development and the parallel approach to controlling endogenous β-cell neogenesis.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Diabetes; MAPC; cell therapy; directed differentiation; embryonic stem cell; insulin; β cell; pancreas development; stem cell

Document Type: Research Article

Publication date: 2005-11-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more