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Clear cell sarcoma of the small bowel: a potential pitfall: Case report

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Abstract:

Venkataraman G, Quinn AM, Williams J, Hammadeh R. Clear cell sarcoma of the small bowel: a potential pitfall. APMIS 2005;113:716–19.

Clear cell sarcoma (soft-part melanoma) is a very rare entity with a distinctive histopathologic and molecular profile. Herein, we present the sixth reported case of a primary gastrointestinal clear cell sarcoma discovered in a 21-year-old woman. The patient underwent numerous tests prior to the diagnosis of her small bowel pathology, including the use of capsule endoscopy, which allowed for visualization and final localization of the tumour. Additionally, we discuss this rare type of sarcoma that affects young adults and has a poor prognosis characterized by the balanced chromosomal translocation t(12;22)(q13;q12) with special emphasis on the necessity for pathologists to be able to distinguish it from melanoma – potentially a major pitfall in diagnosis.

Keywords: Clear cell sarcoma; immunohistochemistry

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2005.apm_243.x

Affiliations: 1: Internal Medicine, Loyola University Medical Center, Maywood, Illinois, USA 2: Pathology and

Publication date: October 1, 2005

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