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Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens

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Abstract:

Drago L, De Vecchi E, Nicola L, Legnani D, Gismondo MR. Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens. APMIS 2005;113:655–63.

The present study assessed the comparative in vitro killing kinetics of telithromycin, azithromycin and clarithromycin. Minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) were determined against Streptococcus pneumoniae, β-haemolytic streptococci, Haemophilus influenzae and Moraxella catarrhalis strains characterized by different susceptibilities to β-lactams and macrolides. For each bacterial species, representative strains were chosen for time-kill studies. Telithromycin showed high activity against all the tested strains with MIC ranging from ≤0.004 to 0.5 mg/L for streptococci, from 0.008 to 8 mg/L for H. influenzae, and from 0.008 to 0.5 mg/L for M. catarrhalis. In time-kill studies, telithromycin showed an overall superior bactericidal activity in respect to macrolides, particularly against resistant strains. In conclusion, telithromycin proved to possess bactericidal activity against a wide range of respiratory pathogens, including strains resistant to common macrolides.

Keywords: Haemophilus influenzae; Moraxella catarrhalis; Telithromycin; macrolides; streptococci

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2005.apm_195.x

Affiliations: 1: Laboratory of Clinical Microbiology, Department of Clinical Sciences L. Sacco and 2: Institute of Respiratory Diseases, University of Milan, Milan, Italy

Publication date: October 1, 2005

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