Ovarian ependymoma: Case report

Authors: ERDOGˇAN, GÜLGÜN; ÖZEL, ESIN¹; PEŞTERELI, HADICE ELIF¹; SALAR, ZEKI²; TIRAK, BILAL²; KARAVELI, ŞEYDA¹

Source: Apmis, Volume 113, Number 4, April 2005 , pp. 301-303(3)

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Abstract:

ErdoGˇan G, Özel E, Peştereli HE, Salar Z, Tırak B, Karaveli S. Ovarian ependymoma. Case report. APMIS 2005;113:301–3.

A 76-year-old woman presented with a large calcifying mass behind the bladder. The tumor contained solid areas of a yellowish white color. Microscopic examination revealed highly cellular solid areas with many typical ependymal perivascular pseudorosettes. The cells contained uniform round-to-oval nuclei, some of which had irregular contours, clumped chromatin and occasional prominent nucleoli. There was widespread geographic necrosis and there were 5 atypical mitotic figures per 10 high power fields. Glial fibrillary acidic protein (GFAP) immunopositivity was observed in the cytoplasm of the tumor cells. Based on the histopathologic and immunohistochemical features, the tumor was diagnosed as an anaplastic ependymoma. This is to the best of our knowledge only the second case of anaplastic ependymoma in the medical literature.

Keywords: Ovary; primary neuroectodermal tumors; ependymoma

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2005.apm_10.x

Affiliations: 1: Department of Pathology, Akdeniz University School of Medicine, and 2: Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey

Publication date: 2005-04-01