Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens: Brief report

Authors: MAYO, SUSAN; ROYO, FELIX; HAU, JANN

Source: Apmis, Volume 113, Number 4, April 2005 , pp. 284-287(4)

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Abstract:

Mayo S, Royo F, Hau J. Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens. Brief report. APMIS 2005;113:284–7.

The aim of the present study was to investigate whether the adjuvanticity of the cholera toxin B (CTB) subunit was correlated with its immunogenicity in young orally immunised chickens. Thirteen 15-day-old chickens were orally immunised with bovine serum albumin (BSA) glutaraldehyde coupled to CTB. The chicken antibody (IgG) concentrations against BSA and CTB, respectively, were quantified by ELISA. A significant positive correlation (r=0.66, n=39, p<0.001) between the concentrations of immunospecific antibodies with specificities against BSA and CTB, respectively, demonstrated that the adjuvanticity of CTB is correlated with its immunogenicity.

Keywords: Adjuvant; chicken; cholera toxin B

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2005.apm_07.x

Affiliations: 1: Department of Neuroscience, Division of Comparative Medicine, Uppsala University, Uppsala, Sweden

Publication date: 2005-04-01