Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens: Brief report
Authors: MAYO, SUSAN; ROYO, FELIX; HAU, JANN
Source: Apmis, Volume 113, Number 4, April 2005 , pp. 284-287(4)
Abstract:Mayo S, Royo F, Hau J. Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens. Brief report. APMIS 2005;113:284–7.
The aim of the present study was to investigate whether the adjuvanticity of the cholera toxin B (CTB) subunit was correlated with its immunogenicity in young orally immunised chickens. Thirteen 15-day-old chickens were orally immunised with bovine serum albumin (BSA) glutaraldehyde coupled to CTB. The chicken antibody (IgG) concentrations against BSA and CTB, respectively, were quantified by ELISA. A significant positive correlation (r=0.66, n=39, p<0.001) between the concentrations of immunospecific antibodies with specificities against BSA and CTB, respectively, demonstrated that the adjuvanticity of CTB is correlated with its immunogenicity.
Document Type: Research Article
Affiliations: Department of Neuroscience, Division of Comparative Medicine, Uppsala University, Uppsala, Sweden
Publication date: April 1, 2005