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Follicular lymphoid hyperplasia of the oral cavity representing progressive transformation of germinal center: Case report

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Kojima M, Nakamura S, Iijima M, Yoshizumi T, Sakata N, Masawa N. Follicular lymphoid hyperplasia of the oral cavity representing progressive transformation of germinal center. APMIS 2005;113:221–4.

Follicular lymphoid hyperplasia (FLH) of the oral cavity is a rare and poorly understood lymphoproliferative disorder. We present a case of FLH of the oral cavity presenting with progressive transformation of germinal center (PTGC). The patient was a 49-year-old Japanese woman presenting with a hard mass in the right cheek. The resected specimen contained numerous lymphoid follicles with active germinal centers and a portion of the lymphoid follicles exhibited PTGC. The PTGCs contained a few large lymphoid cells resembling lymphocytic and histiocytic Reed-Sternberg cells of nodular lymphocyte-predominant Hodgkin lymphoma. The PTGC was surrounded by groups of epithelioid cells. In situ hybridization studies demonstrated strong expression of Epstein-Barr virus (EBV)-encoded small RNA in scattered large lymphoid cells in the PTGC. Although the etiology of FLH of the oral cavity remains unclear, the present case suggests that a subset of FLH of the oral cavity appears to be an EBV-associated lymphoproliferative disorder.
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Keywords: Epstein-Barr virus; Follicular lymphoid hyperplasia; oral mucosa; progressive transformation of germinal center

Document Type: Research Article

Affiliations: 1: Department of Pathology and Genetics, Aichi Cancer Center Hospital, Nagoya, 2: Pathology and Clinical Laboratories, and 3: Head and Neck Surgery, Gunma Cancer Center Hospital, Ohta, 4: Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan 5: Department of Pathology, Dokkyo University School of Medicine, Mibu,

Publication date: 2005-03-01

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