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Cross-reactivity between human adenoviruses in delayed-type hypersensitivity

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Abstract:

Bakay M, Szalay K, Beladi I, Balint E, Lengyel A, Adam E, Olah T. Cross-reactivity between human adenoviruses in delayed-type hypersensitivity. APMIS 2005;113:197–202.

The aim of this study was to determine the antigen responsible for the induction of delayed-type hypersensitivity (DTH) by human adenoviruses (Ads). The estimation of DTH was based on measurement of the extent of swelling of the hind footpads of mice. CsCl density gradient-purified human Ad serotype 6 (Ad6) induced DTH in a dose-dependent manner. In Ad6-sensitized mice, DTH could be elicited by serotypes belonging to the same species of human Ads (types 1 and 5) and by a serotype (type 3) belonging to another species. Latex particles coated with purified hexon antigen prepared from Ad5 had the capacity to sensitize mice and elicit a DTH reaction. We suggest that, for serotypes belonging to species C, the cross-reactive highly conserved T cell epitope of the hexon protein might be responsible for the DTH induction, and furthermore the same epitope might result in the cross-reactivity between serotypes 3 and 6. The possible importance of these data is discussed in relation to human gene therapy through the application of Ad vectors.

Keywords: Human adenoviruses; cross-reactivity; delayed-type hypersensitivity; hexon protein

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2005.apm1130307.x

Affiliations: 1: Medical Microbiology 2: Optics and Quantum Electronics, University of Szeged, 3: Institute of Medical Microbiology, Semmelweis University, Budapest, 4: Surgical Department, Teaching Hospital, Szeged, Hungary

Publication date: March 1, 2005

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