Skip to main content

Cross-reactivity between human adenoviruses in delayed-type hypersensitivity

Buy Article:

$43.00 plus tax (Refund Policy)

Bakay M, Szalay K, Beladi I, Balint E, Lengyel A, Adam E, Olah T. Cross-reactivity between human adenoviruses in delayed-type hypersensitivity. APMIS 2005;113:197–202.

The aim of this study was to determine the antigen responsible for the induction of delayed-type hypersensitivity (DTH) by human adenoviruses (Ads). The estimation of DTH was based on measurement of the extent of swelling of the hind footpads of mice. CsCl density gradient-purified human Ad serotype 6 (Ad6) induced DTH in a dose-dependent manner. In Ad6-sensitized mice, DTH could be elicited by serotypes belonging to the same species of human Ads (types 1 and 5) and by a serotype (type 3) belonging to another species. Latex particles coated with purified hexon antigen prepared from Ad5 had the capacity to sensitize mice and elicit a DTH reaction. We suggest that, for serotypes belonging to species C, the cross-reactive highly conserved T cell epitope of the hexon protein might be responsible for the DTH induction, and furthermore the same epitope might result in the cross-reactivity between serotypes 3 and 6. The possible importance of these data is discussed in relation to human gene therapy through the application of Ad vectors.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Human adenoviruses; cross-reactivity; delayed-type hypersensitivity; hexon protein

Document Type: Research Article

Affiliations: 1: Medical Microbiology 2: Optics and Quantum Electronics, University of Szeged, 3: Institute of Medical Microbiology, Semmelweis University, Budapest, 4: Surgical Department, Teaching Hospital, Szeged, Hungary

Publication date: 2005-03-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more