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The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia

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Abstract:

Akkaya H, Dogan O, Agan M, Dincol G. The value of tatrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia. APMIS 2005;113:162–6.

Hairy cell leukemia (HCL) is a rare chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia, and circulating atypical lymphocytes with circumferential cytoplasmic projections. We investigated the specificity and the sensitivity of anti-TRAP antibody immunoreactivity in 57 cases of HCL. We found that there is a statistically highly significant difference between TRAP immunoreactivities of the study and the control groups, and HCL can be diagnosed by TRAP immunoreactivity in bone marrow trephine biopsy materials with a specificity of 98.27 % and a sensitivity of 100%.

Keywords: Hairy cell leukemia; TRAP; bone marrow trephine biopsy; immunohistochemistry

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2005.apm1130302.x

Affiliations: 1: Pathology and 2: Hematology Departments, Istanbul University, Medical Faculty, Istanbul

Publication date: March 1, 2005

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