Exacerbation of protracted-relapsing experimental allergic encephalomyelitis in DA rats by gluten-free diet

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Abstract:

Di Marco R, Mangano K, Quattrocchi C, Amato F, Nicoletti F, Buschard K. Exacerbation of protracted-relapsing experimental allergic encephalomyelitis in DA rats by gluten-free diet. APMIS 2004;112:651–5.

The observation of neurological dysfunctions resembling multiple sclerosis (MS) seen clinically and/or by MRI in patients with celiac disease has focused attention on the possibility that cryptic gluten sensitivity may be involved in the pathogenesis of MS. Here we study the effects of a gluten-free diet on the course of protracted-relapsing EAE in DA rats, serving as a preclinical model of human MS. The data show not only that this nutritional approach failed to ameliorate development of the disease but rather that it exacerbated the course.

Keywords: DA rats; EAE; Gluten-free diet; MS; celiac disease; experimental allergic encephalomyelitis; multiple sclerosis; paresis; type 1 diabetes mellitus

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2004.apm1121003.x

Affiliations: 1: Department of Microbiological and Gynaecological Sciences, School of Medicine, University of Catania, 2: Department of Biomedical Sciences, School of Medicine, University of Catania, Italy 3: Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark

Publication date: October 1, 2004

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