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Homocysteine and the production of collagens, proliferation and apoptosis in human arterial smooth muscle cells

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Abstract:

Rasmussen LM, Hansen PR, Ledet T. Homocysteine and the production of collagens, proliferation and apoptosis in human arterial smooth muscle cells. APMIS 2004;112:598–604.

Homocysteine (H(e)) is an important and independent risk factor for atherosclerosis. We showed that human aortic smooth muscles in cultures proliferated significantly at a concentration of 25 μmol/L H(e) without the presence of serum. There was no effect of H(e) on apoptosis as determined by TUNEL-assay and gene expression of proapoptotic protein bax, caspases and TNFα families. However, collagen types I, III and IV increased significantly in a dose-dependent manner at elevated concentrations of H(e) and the amount of type VI collagen was significantly reduced in a dose-dependent manner. H(e) induced increased cell replication with an unaffected apoptosis rate. The present observations suggest that H(e) may contribute to accelerated progression of atherosclerotic lesions with collagen alterations which transform the injury into fibrotic plaques.

Keywords: Apoptosis genes; atherosclerosis; collagen types; homocysteine; plaque formation; smooth muscle cells

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0463.2004.apm1120907.x

Affiliations: 1: Research Laboratory for Biochemical Pathology, Aarhus Universitetshospital, 8000 Aarhus C, 2: Department of Cardiology P, Gentofte University Hospital, 2900 Hellerup, Denmark

Publication date: 2004-09-01

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