Ginseng modulates the immune response by induction of interleukin-12 production
Authors: LARSEN, MARIA WALDORFF; MOSER, CLAUS; HØIBY, NIELS; SONG, ZHIJUN; KHARAZMI, ARSALAN
Source: Apmis, Volume 112, Number 6, June 2004 , pp. 369-373(5)
Abstract:Larsen MW, Moser C, Høiby N, Song Z, Kharazmi A. Ginseng modulates the immune response by induction of interleukin-12 production. APMIS 112;2004:369–73.
In infections with intracellular microorganisms such as mycobacteria and Leishmania parasites as well as certain extracellular chronic infections such as Pseudomonas aeruginosa a Th1 response with activation of macrophages is desirable. Several studies indicate that such a response is associated with better recovery from infection, improved course of the chronic infection, and higher survival rate. In Th1 responses there is increased interferon-γ (IFN-γ) and interleukin-12 (IL-12) production, whereas that of interleukin-10 (IL-10) is decreased. The present study indicated that Ginseng modulation of stimulated peripheral blood mononuclear cells (PBMC) results in a higher IL-12 production. The enhanced IL-12 production could induce a stronger Th1 response, resulting in better protection against infection with a variety of pathogens.
Document Type: Research Article
Affiliations: Department of Clinical Microbiology, University Hospital (Rigshospitalet), afsnit 7602, Copenhagen, Denmark
Publication date: June 2004