Skip to main content

Expression of non-membranous β-catenin and γ-catenin, c-Myc and cyclin D1 in relation to patient outcome in human colon adenocarcinomas

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Bondi J, Bukholm G, Nesland JM, Bukholm IRK. Expression of non-membranous β-catenin and γ-catenin, c-Myc and cyclin D1 in relation to patient outcome in human colon adenocarcinomas. APMIS 2004;112:49–56.

Non-membranous β-catenin and γ-catenin, c-Myc and cyclin D1 are key participants in the Wnt cell signalling pathway, in which aberrancies have been associated with malignant cell transformation. We assessed the independent prognostic value of these proteins in a clinical material. Tumours from a series of 162 patients operated on for Dukes' stage A, B and C colonic adenocarcinomas were analysed using semiquantitative immunohistochemistry and the results were related to patient outcome. Patients expressing nuclear β-catenin in the primary tumour showed reduced survival compared to other patients (log rank p=0.028) and there was also an association with development of metastases follow-up (logistic regression p=0.024). Using multivariate analysis (Cox regression) co-expression of nuclear β-catenin and c-Myc turned out to be the strongest marker of impaired prognosis (p=0.001, HR 5.26, 95% CI 1.93–14.36). Expression of non-membranous γ-catenin, cyclin D1 and c-Myc alone failed to have independent prognostic significance in our study.

Keywords: c-Myc; colon cancer; cyclin D1; immunohistochemistry; prognosis; β-catenin; γ-catenin

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0463.2004.apm1120109.x

Publication date: 2004-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more