Skip to main content

The role of dendritic cells in the pathogenesis of HIV-1 infection

Buy Article:

$51.00 plus tax (Refund Policy)


Loré K, Larsson M. The role of dendritic cells in the pathogenesis of HIV-1 infection. APMIS 2003;111:776–88.

Dendritic cells are professional antigen-presenting cells required for generation of adaptive immunity. These cells are one of the initial target cells for HIV-1 infection or capture of virions at site of transmission in the mucosa. DCs carrying HIV-1 will migrate to the lymphoid tissue where they can contribute to the dissemination of the virus to adjacent CD4+ T cells. In addition, HIV-1–exposed DCs may have impaired antigen-presenting capacity resulting in inadequate expansion of HIV-1–specific T cell responses. Here, we review the infection of different subtypes of DCs by HIV-1 and the relevance of these cells in the transmission and establishment of HIV-1 disease. In addition, we discuss the mechanisms through which HIV-1–DC interactions could be exploited to optimise the generation and maintenance of HIV-1–specific T cell immunity.

Keywords: Dendritic cells; HIV-1 infection; adaptive immunity; pathogenesis

Document Type: Research Article


Affiliations: The Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, USA

Publication date: July 1, 2003

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more