Skip to main content

The role of dendritic cells in the pathogenesis of HIV-1 infection

Buy Article:

$43.00 plus tax (Refund Policy)

Loré K, Larsson M. The role of dendritic cells in the pathogenesis of HIV-1 infection. APMIS 2003;111:776–88.

Dendritic cells are professional antigen-presenting cells required for generation of adaptive immunity. These cells are one of the initial target cells for HIV-1 infection or capture of virions at site of transmission in the mucosa. DCs carrying HIV-1 will migrate to the lymphoid tissue where they can contribute to the dissemination of the virus to adjacent CD4+ T cells. In addition, HIV-1–exposed DCs may have impaired antigen-presenting capacity resulting in inadequate expansion of HIV-1–specific T cell responses. Here, we review the infection of different subtypes of DCs by HIV-1 and the relevance of these cells in the transmission and establishment of HIV-1 disease. In addition, we discuss the mechanisms through which HIV-1–DC interactions could be exploited to optimise the generation and maintenance of HIV-1–specific T cell immunity.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Dendritic cells; HIV-1 infection; adaptive immunity; pathogenesis

Document Type: Research Article

Affiliations: The Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, USA

Publication date: 01 July 2003

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more