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Dendritic cells in peripheral tolerance and immunity

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Gad M, Claesson MH, Pedersen AE. Dendritic cells in peripheral tolerance and immunity. APMIS 2003;111:766–75.

Dendritic cells capable of influencing immunity exist as functionally distinct subsets, T cell-tolerizing and T cell-immunizing subsets. The present paper reviews how these subsets of DCs develop, differentiate and function in vivo and in vitro at the cellular and molecular level. In particular, the role of DCs in the generation of regulatory T cells is highlighted.

Keywords: Dendritic cells; immunity; regulatory T cells; tolerance; toll-like receptors

Document Type: Research Article


Affiliations: Laboratory of Cellular Immunology, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

Publication date: July 1, 2003

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