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Elevated number of cells secreting transforming growth factor β in Guillain-Barré syndrome

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Abstract:

Dahle C, Kvarnström M, Ekerfelt C, Samuelsson M, Ernerudh J. Elevated number of cells secreting transforming growth factor β in Guillain-Barré syndrome. APMIS 2003;111:1095–104.

We used ELISPOT and cell ELISA to study secretion of IL-4, IFN-γ, TGF-β, IL-6, and TNF-α by circulating mononuclear cells during the course of Guillain-Barré syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF-β-secreting cells and the number of individuals with myelin-peptide-induced IL-4 and TGF-β secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro-inflammatory cytokines IFN-γ, IL-6 or TNF-α. Our findings indicate a down-regulatory role for TGF-β and IL-4 in GBS.

Keywords: ELISPOT; Guillain-Barré syndrome; IL-4; TGF-β; cytokines

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2003.apm1111204.x

Affiliations: 1: Division of Clinical Immunology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University Hospital, and 2: Neurology unit, Örebro University Hospital, Sweden

Publication date: December 1, 2003

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