Skip to main content

Mutational analysis of salvador gene in human carcinomas

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Yoo NJ, Soung YH, Lee JW, Park WS, Han JH, Kim SH, Lee JY and Lee SH. Mutational analysis of salvador gene in human carcinomas. APMIS 2003;111:595–8.

It is believed that clonal expansion and cancer growth is the result of the deregulation of proliferation and cell death. Recently, salvador, a molecule that can regulate both cell proliferation and cell death, was identified. It was also reported that human salvador (hWW45) is mutated in some cancer cell lines. However, there have been no data regarding salvador gene mutations in human cancer tissues. To explore the hypothesis that the salvador gene might be similarly mutated in human cancer tissues, we analyzed the entire coding region of the salvador gene for the detection of somatic mutations in a series of human cancer tissues, including carcinomas from stomach, colon, liver and lung. However, using SSCP analysis, no mutation in the coding and splicing regions could be detected in the cancers. The data presented here suggest that salvador is not frequently mutated in human carcinoma tissues and that the mutation might be tumor-type specific.

Keywords: Salvador; apoptosis; carcinoma; hWW45; mutation

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1600-0463.2003.1110601.x

Affiliations: 1: Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea; and 2: Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea

Publication date: June 1, 2003

mksg/apm/2003/00000111/00000006/art00001
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more