Coronary thrombosis and sudden death after an enteroviral infection: Case report

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Calabrese F, Basso C, Valente M & Thiene G. Coronary thrombosis and sudden death after an enteroviral infection. Case report. APMIS 2003;111:315–8

We report the case of a 26–year-old man who died suddenly 9 days after an episode of flu. Microscopic examination of the left anterior descending coronary artery showed an eccentric fibroatheromatic plaque complicated by thrombosis, endothelial erosion and extensive T-cell and macrophage infiltration. Frozen sections of the thrombotic coronary segment, analysed for different infective agents by polymerase chain reaction (PCR) and reverse transcriptase (RT)-PCR, showed positive amplification for an enteroviral genome. Enteroviral infection may play an important role in coronary plaque instability and may precipitate thrombotic occlusion.

Keywords: Coronary thrombosis; enteroviral infection; sudden death

Document Type: Research Article


Affiliations: Department of Pathology, University of Padua Medical School, Padua, Italy

Publication date: February 1, 2003

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