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Germ cell tumours in neonates and infants: a distinct subgroup?

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Veltman IM, Schepens MT, Looijenga LHJ, Strong LC, Geurts van Kessel A. Germ cell tumours in neonates and infants: a distinct subgroup? APMIS 2003;111:152–60.

Human germ cell tumours (GCTs) constitute a heterogeneous group of tumours that can be classified into four major subgroups. One of these subgroups encompasses (immature) teratomas and yolk sac tumours of patients under the age of 5 years. In this paper we review the various clinical, histological and cytogenetical aspects of these infantile GCTs. The primordial germ cell (PGC) has been suggested to be the cell of origin for GCTs. Infantile GCTs, however, have been suggested to originate from PGCs at a different stage of maturation than adult GCTs. The cytogenetic constitution of infantile GCTs also appears to differ from the adult GCTs and includes recurrent losses of 1p and 6q. Recently, two cases of infantile GCT were detected with constitutional 12q13 translocations. These exceptional cases may be instrumental in the search for candidate genes related to infantile and/or adult GCT development.

Keywords: 12q13 constitutional translocations; 1p and 6q losses; Infantile; teratoma

Document Type: Research Article


Affiliations: 1: Dept. of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands, 2: Pathology/Lab. for Exp. Patho-Oncology, Erasmus University Medical Center Rotterdam, Daniel Josephine Nefkens Institute, Rotterdam, The Netherlands, 3: Dept. of Exp. Pediatrics/Genetics, UT M. D. Anderson Cancer Center, Houston, USA

Publication date: 2003-01-01

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