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A new prognostic model for testicular germ cell tumours

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Abstract:

von Eyben FE, Madsen EL, Fritsche H, Suciu G, Liu F, Amato R. A new prognostic model for testicular germ cell tumours. APMIS 2003;111:100–5.

In univariate analyses of patients with metastatic testicular germ cell tumours (TGCT), both the International Germ Cell Consensus Classification (IGCCC) and serum lactate dehydrogenase (S-LD) isoenzyme 1 catalytic concentration (S-LD-1) significantly predicted survival. In complementary analyses of 81 patients with metastatic TGCT, S-LD and S-LD-1 classified the prognosis differently for 23 patients. In multivariate Cox hazard analyses of risk factors, only IGCCC and S-LD-1 predicted the prognosis (p=0.036, and p=0.0007, respectively). A new prognostic model based on prognostic information from main histology, IGCCC, and S-LD-1 changed the prognostic prediction by IGCCC for 19 patients (24%). Judged by to the area under the curve for receiver operation characteristics curves, the new model predicted five-years survival for the patients better than IGCCC and a modified version of the third edition of the TNM classification (p=0.025, and p=0.01, respectively). However, new studies should validate the new model before it is recommended as a general classification system of patients with metastatic TGCT.

Keywords: Testicular neoplasms; alpha fetoproteins; human chorionic gonadotropin; lactate dehydrogenase isoenzymes; multivariate analyses; prognosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1600-0463.2003.1110114_1.x

Affiliations: 1: Department of Oncology, Soenderborg Hospital, Denmark, and 2: Division of Clinical Chemistry, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 3: Department of Biostatistics, Ohio State University, Columbia, Ohio, and 4: Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA

Publication date: January 1, 2003

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