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The effects of enoxaparin on the reparative processes in experimental osteonecrosis of the femoral head of the rat

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The blood supply of one femoral head of 6-month-old rats was severed by incising the periosteum of the neck and cutting the ligamentum teres. The rats were killed on the 30th postoperative day and the femoral bones were obtained for semiquantification of the reparative processes in the necrotic heads. Fourteen rats were treated with enoxaparin and 14 untreated animals served as controls. Statistically, the amounts of necrotic bone in the epiphysis were less, the extent of remodeling of the femoral heads was milder, and the articular cartilage degeneration was slighter in the enoxaparin-treated than untreated rats. There was no significant difference in the quantities of newly formed bone in femoral heads of treated and untreated rats. These findings are in agreement with the known effects of unfractionated and low-molecular-weight heparins which enhance osteoclastic bone resorption and angiogenesis and decrease osteoblastic bone formation. The former activities, operative in minimizing the structural distortion of the femoral head, oppose the crucial event in the pathogenesis of post-osteonecrotic osteoarthritis.

Keywords: Enoxaparin; Legg-Calvé-Perthes disease; animal model of human disease; osteonecrosis; unfractionated heparin and low-molecular-weight heparin

Document Type: Research Article


Affiliations: 1: Department of Orthopaedic Surgery B, Rambam Medical Center, 2: Department of Pathology, HaCarmel Hospital, and 3: Department of Pathology, Bnai-Zion Medical Center, and the Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel

Publication date: March 1, 2002


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