Skip to main content

Possible health impact of phytoestrogens and xenoestrogens in food

Buy Article:

$48.00 plus tax (Refund Policy)

Abstract:

Plants produce estrogen‐like substances, denominated phytoestrogens, which are present in many human foodstuffs. The consumption of phytoestrogens has been associated with a variety of protective effects. Their relative estrogenic potency combined with their concentrations in food and human plasma indicate biological relevance. However, their biological properties differ from those of estradiol or other endogenous estrogens in humans. For instance, their possible effects on SHBG, inhibition of steroid metabolizing enzymes, anti‐proliferative and anti‐angiogenetic and other side effects have been described. Furthermore, phytoestrogens can exert estrogenic and antiestrogenic activities at the same time and their potency and metabolism have not been yet elucidated in all cases. In recent decades growing evidence has accumulated on the hormone‐like effects of synthetic chemicals that appeared in the environment. The possible impact of xenoestrogens, to which humans are also exposed through the food chain, needs to be further clarified as well. The molecular effects and control mechanisms of these substances, their pharmacokinetics, threshold levels and dose‐response differences are issues that require further research before a full assessment of their effect on humans can be drawn. Evaluating the total exposure and impact of this estrogenic effect is very challenging because of the lack of specific knowledge in some areas and the differences in the biological activity among these substances, as pinpointed in this review.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2001.tb05792.x

Affiliations: 1: Institute for Prospective Technological Studies; Joint Research Centre (EC), Isla de la Cartuja s/n, E-41092 Seville, Spain 2: Institute of Physiology, Technical University Munich-Weihenstephan, D-85350 Freising-Weihenstephan, Germany

Publication date: July 1, 2001

mksg/apm/2001/00000109/A103s103/art00049
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more