Skip to main content

The putative R1 protein of Streptococcus agalactiae as serotype marker and target of protective antibodies

Buy Article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.

The streptococcal R1 protein was studied by means of anti-R1 antibodies prepared by appropriate cross-absorption of rabbit antiserum raised against the group B streptococcal (GBS) strain ATCC 12403 (D136C), serotype III/R1. The protein was a ladder-forming antigen according to banding patterns in immunoblotting, similar to several other GBS proteins, and was susceptible to digestion by both pepsin and trypsin. Antibody-based testing revealed that 10% of Norwegian GBS isolates expressed the R1 protein, most frequently capsular antigen type V strains (72%) and less frequently type III strains (3%). None of 132 GBS strains from Zimbabwe, including 39 type V strains, expressed the R1 protein. R1-specific rabbit antibodies showed protective activity in mice challenged with a GBS type V/R1 strain. The results show that the R1 protein is an important GBS serotype marker in strains from certain geographical areas, notably for the subtyping of capsular type V strains, and that this protein is a target of protective antibodies.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: R1 protein; Streptococcus agalactiae

Document Type: Original Article

Affiliations: 1: Department of Medical Microbiology, University of Zimbabwe Medical School, Harare, Zimbabwe, and 2: Department of Microbiology, The Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Publication date: 2001-12-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more