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A new model for evaluation of thrombosis and ischaemia/reperfusion injury

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Background: The purpose of the present study was to describe infarct size and platelet accumulation when reperfusion injury was combined with a thrombogenic lesion in the coronary artery. The left anterior descending artery was damaged in 11 pigs and subsequently occluded proximal to the lesion for 50 min, followed by 4 h of reperfusion. Results: The infarct size/area at risk was 40 (35–63)%. Infarct size correlated with troponin-T-3 h (p=0.85, p<0.002), but not with creatine kinase-3 h. Platelet aggregation decreased by 34% (p<0.01) at 15 min of reperfusion, but returned to baseline. Platelet accumulation in the left ventricle was significantly higher in the area at risk (194 (157–206)%) compared to the right ventricle (137 (120–142)%); p<0 .05). Conclusion: A decreased platelet reactivity and increased accumulation of platelets in the area at risk indicates that activated platelets become entrapped in the myocardium. Troponin-T was a better marker of myocardial damage than creatine kinase in this in vivo model with pigs.
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Keywords: Animals; infarct size; ischaemic markers; platelets; thrombosis

Document Type: Original Article

Affiliations: 1: Department of Thoracic and Cardiovascular Surgery, Aarhus University Hospital, Denmark 2: Department of Anaesthesiology; 3: Institute of Experimental & Clinical Research;

Publication date: 2000-05-01

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