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Free Content Markers of thrombophilia in retinal vein thrombosis

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To study the prevalence of risk factors for systemic thromboembolism in patients with retinal vein thrombosis (RVT).


Fifty-four patients younger than 70 years, diagnosed with a retinal vein thrombosis at the Department of Ophthalmology, Ã…rhus University Hospital, were examined for the presence of venous thrombosis risk factors.


23 patients had a central RVT, 26 had a branch RVT, and 4 had a macular RVT. Nineteen (35.2%) of the patients displayed increased levels of plasma homocysteine, one patient (1.9%) the Factor V Leiden mutation, and one patient (1.9%) displayed an antiphospholipid antibody. All other tests for thrombophilia rendered normal. In 15 of the patients with hyperhomocysteinemia, folic acid substitution returned plasma homocysteine to a normal value in 12 cases.


A surprisingly high prevalence of hyperhomocysteinemia was detected in this cohort of RVT patients, clearly superseding the prevalence of around 17% found in patients suffering venous thromboembolism in other vascular compartments. Our finding points to the likelihood that hyperhomocysteinemia may be a significant risk factor for retinal vein thrombosis.

Keywords: genetic abnormalities; hyperhomocysteinemia; retinal vein thrombosis; risk factor

Document Type: Original Article

Affiliations: 1: The Department of Ophthalmology and Centre for Haemophilia and Thrombosis, Department of Clinical Immunology 2: , University Hospital Aarhus/Skejby, Aarhus, Denmark

Publication date: 2000-10-01

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