Free Content Malignant changes in a giant orbital keratoacanthoma developing over 25 years

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To report a patient with a history over 25 years of a slowly growing, large, invasive crateriform tumour filling the anterior part of the orbit.


A 61-year-old male presented with a large tumour of the left orbit. Exenteration was performed with subsequent histological analysis of the excised mass.


The main tumour showed the characteristic features of a keratoacanthoma. However, the posterior aspect of the tumour disclosed the morphology of a squamous cell carcinoma. Six months later, the patient presented with metastases to lymph nodes, lung and mediastinal tissue. A leukemoid reaction was diagnosed by fine needle biopsy.


The giant variety of keratoacanthoma may fail to regress and can transform into a squamous cell carcinoma. In our patient, the development of a chronic lymphoid leukemia raises the possibility that it may be the underlying cause for the transformation of the posterior part of the keratoacanthoma into a frank squamous cell carcinoma.

Keywords: benign; histopathology; immunohistochemistry; keratoacanthoma; malignant; orbit; squamous cell carcinoma; tumour

Document Type: Case Report

Affiliations: Eye Pathology Institute, University of Copenhagen, Denmark

Publication date: April 1, 2000

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