Skip to main content

Free Content Malignant changes in a giant orbital keratoacanthoma developing over 25 years

Download Article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.

Abstract:

ABSTRACT.Purpose:

To report a patient with a history over 25 years of a slowly growing, large, invasive crateriform tumour filling the anterior part of the orbit.

Methods:

A 61-year-old male presented with a large tumour of the left orbit. Exenteration was performed with subsequent histological analysis of the excised mass.

Results:

The main tumour showed the characteristic features of a keratoacanthoma. However, the posterior aspect of the tumour disclosed the morphology of a squamous cell carcinoma. Six months later, the patient presented with metastases to lymph nodes, lung and mediastinal tissue. A leukemoid reaction was diagnosed by fine needle biopsy.

Conclusion:

The giant variety of keratoacanthoma may fail to regress and can transform into a squamous cell carcinoma. In our patient, the development of a chronic lymphoid leukemia raises the possibility that it may be the underlying cause for the transformation of the posterior part of the keratoacanthoma into a frank squamous cell carcinoma.

Keywords: benign; histopathology; immunohistochemistry; keratoacanthoma; malignant; orbit; squamous cell carcinoma; tumour

Document Type: Case Report

Affiliations: Eye Pathology Institute, University of Copenhagen, Denmark

Publication date: 2000-04-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more