Free Content Lacrimal canalicular stenosis associated with systemic 5-fluorouracil therapy

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Ocular side effects of systemic 5-fluorouracil therapy include excessive lacrimation which often resolves on cessation of therapy. Permanent stenosis of lacrimal puncta and canaliculi is rare. This report highlights this uncommon complication of 5-fluorouracil therapy.


Report of two cases and review of literature.


Severe stenosis of puncta and canaliculi may be associated with prolonged systemic 5-fluorouracil therapy.


It is important for both the oncologist and ophthalmologist to be aware of the potential ocular toxicity of 5-fluorouracil. Surgical management to relieve the epiphora is often challenging, and early intervention may be beneficial.

Keywords: 5-fluorouracil (5-FU); canalicular stenosis; cancer chemotherapy; drug side effects; epiphora; ocular toxicity

Document Type: Case Report

Affiliations: Department of Ophthalmology, Arrowe Park Hospital, Upton, Wirral, United Kingdom

Publication date: February 1, 2000

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