Free Content Choroidal Langerhans' cell histiocytosis

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To report a patient with choroidal Langerhans' cell histiocytosis.


A solitary tumor was found in the left eye of a 49-year-old male who had no definite history of systemic disorders, but had observed visual disturbances for a period of 1 month. Ultrasonography, fluorescein angiography, and indocyanine green angiography were performed and the eyeball was enucleated. We prepared the specimen for microscopic examinations.


Fluorescein angiographic findings of the lesion were mottled hyperfluorescence in the arteriovenous phase and strong hyperfluorescence in the late phase. Hypofluorescence in both early and late phases showed on indocyanine green angiogram. The lesion of choroid was widely infiltrated by histiocytes, though no extraocular invasion was found. Immunohistochemical studies including S-100 and CD 68 staining revealed characteristic features of Langerhans' cell histiocytosis. Electron microscopic examination of the histiocytes showed histiocytosis X body (Birbeck granule) in the cytoplasm and indented nucleus.


We consider that this is a case of choroidal Langerhans' cell histiocytosis with no evidence of systemic lesions.

Keywords: Langerhans' cell histiocytosis; choroid; fluorescein angiography; histiocytosis X body; indocyanine green angiography

Document Type: Case Report

Affiliations: Department of Ophthalmology, School of Medicine, Kyungpook National University, Taegu, South Korea

Publication date: February 1, 2000

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