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ABSTRACT.Purpose: The aim of this prospective study was to assess the ocular hemodynamic changes in patients with Behçet's disease who had involvement of the posterior segment by color Doppler ultrasonography. Methods: The present study was carried out in 32 eyes of 24 patients with ocular Behçet's disease and 42 eyes of 21 persons as a healthy age-matched control group. In order to detect the hemodynamic changes in ocular Behçet's disease, peak systolic and end-diastolic velocities (PSV, EDV; cm/sec), resistive and pulsatile indices (RI, PI), and PSV/EDV ratio of central retinal artery (CRA), short posterior ciliary artery (PCA) and ophthalmic artery (OA) were determined. Results: The mean PSV and EDV (8.1±2.6 and 2.7±0.1 cm/sec, respectively) in the CRA were significantly lower in patients with Behçet's disease than in healthy controls (11.5±2.2 and 3.5±1.0 cm/sec, respectively, p<0.001). For the PCA, these values (12.7±4.2 and 4.3±1.1 cm/sec, respectively) were significantly lower in the patient group than in the control the group (18.2±4.2 and 6.1±2.5 cm/sec, respectively, p<0.001). In the patient group, a statistically significant decrease compared to the control group was detected in the mean PSV of the OA (31.8±8.2 and 35.8±0.6 cm/sec, respectively, p<0.02). However, no significant difference in the other parameters of these vessels was observed between groups. Conclusions: These results demonstrate the presence of some circulatory changes in the flow velocities of the CRA, PCA and OA in patients with Behçet's disease when compared with control subjects.