Clinical heterogeneity in Parkinson’s disease revisited: a latent profile analysis
Methods – LPA utilizing clinical variables while controlling for age was applied to a cohort of 71 outpatients with PD. The resultant subgroups were validated via comparison to 30 control subjects on neuropsychological tests of executive, memory, and visuospatial functions.
Results – The LPA resulted in a three‐class solution identifying a ‘younger onset, mild motor impairment group’, a ‘moderate motor impairment group’, and an ‘old onset, fast progression group’. The groups were distinguishable on cognitive variables with the ‘younger onset mild motor impairment subgroup’ displaying deficits pertaining verbal acquisition, visuospatial construction, and set maintenance. The ‘moderate motor impairment group’ exhibited widespread cognitive impairment, and the ‘old onset, fast disease progression group’ had extensive cognitive impairment but outperformed the former group on verbal acquisition and visuospatial function.
Conclusion – LPA holds promise in PD research as it uncovered three PD subtypes distinguished by motor symptoms and disease progression and validated by cognitive variables.
Document Type: Research Article
Affiliations: 1: Department of Psychology, Aarhus University, Aarhus C, Denmark 2: School of Psychology and Psychology Research Institute, University of Ulster, Londonderry, Northern Ireland 3: Department of Nuclear Medicine, Aarhus University Hospitals, Aarhus C, Denmark 4: Department of Neurology, Aarhus University Hospitals, Aarhus C, Denmark
Publication date: 2012-05-01