Galantamine and behavior in Alzheimer disease: analysis of four trials
Kavanagh S, Gaudig M, Van Baelen B, Adami M, Delgado A, Guzman C, Jedenius E, Schäuble B. Galantamine and behavior in Alzheimer disease: analysis of four trials. Acta Neurol Scand: 2011: 124: 302–308. © 2011 John Wiley & Sons A/S.
Many individuals with Alzheimer’s disease (AD) experience behavioral and neuropsychiatric symptoms, which may cause caregiver distress and lead to the institutionalization of the patient. This analysis characterized behavioral symptoms and caregiver distress in trials of galantamine
and their response to treatment.
Materials and methods – Data were pooled from four randomized, placebo‐controlled clinical trials of galantamine in patients with mild to moderate AD (three studies) or AD plus cerebrovascular disease (one study) (n = 2177).
Behavior and associated caregiver distress were assessed in each study using the Neuropsychiatric Inventory (NPI) and NPI distress (NPI‐D), respectively.
Results – After 5/6 months, but not after 3 months, NPI score was significantly improved with
galantamine vs placebo (P = 0.013). The benefit was particularly pronounced in patients categorized as having advanced moderate AD. At 5/6 months, there was a numerical benefit of galantamine over placebo in terms of caregiver distress; the difference was statistically
significant in patients with moderate or advanced moderate AD.
Conclusions – Galantamine reduces behavioral symptoms in patients with mild to moderate AD, leading to reduced caregiver burden. The reductions were greatest in patients with moderate or advanced moderate
Document Type: Research Article
Johnson & Johnson Pharmaceutical Services, Beerse, Belgium
Janssen–Cilag GmbH, Neuss, Germany
SGS Life Science Services, Mechelen, Belgium
Janssen–Cilag, Milan, Italy
Janssen–Cilag, Paris, France
Janssen–Cilag, Madrid, Spain
Janssen–Cilag, Stockholm, Sweden
Publication date: November 1, 2011