Skip to main content

Lipid peroxidation in Alzheimer’s Disease: emphasis on metal‐mediated neurotoxicity

Buy Article:

$51.00 plus tax (Refund Policy)


Obulesu M, Venu R, Somashekhar R. Lipid peroxidation in Alzheimer’s Disease: emphasis on metal‐mediated neurotoxicity. Acta Neurol Scand: 2011: 124: 295–301. © 2011 John Wiley & Sons A/S.

Despite the crucial role of redox active metals like copper and iron in central biological reactions, their elevated levels are involved in the pathogenesis of Alzheimer’s Disease (AD). Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS. Iron, copper, and zinc are some of the metals, which intensify this process and contribute for the pathogenesis of AD. This review summarizes the mechanism of ROS/RNS production and their role in lipid peroxidation. The factors, which make brain vulnerable for lipid peroxidation, have been discussed. It also focuses on possible treatment options and future directions.

Document Type: Research Article


Affiliations: Department of Biotechnology, Capital College, Bangalore, India

Publication date: November 1, 2011


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more