Acute postoperative seizures after epilepsy surgery – a long-term outcome predictor?
Source: Acta Neurologica Scandinavica, Volume 123, Number 1, January 2011 , pp. 48-53(6)
Abstract:Alfstad KÅ, Lossius MI, Røste GK, Mowinckel P, Scheie D, Borota OC, Larsson PG, Nakken KO. Acute postoperative seizures after epilepsy surgery – a long-term outcome predictor?
Acta Neurol Scand: 2011: 123: 48–53.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. Objectives –
The prognostic value of acute postoperative seizures (APS) after epilepsy surgery is much debated. This study evaluated APS, defined as seizures in the first week post-surgery, as a predictor of long-term seizure outcome, and investigated the utility of other potential outcome predictors. Materials and methods –
Medical records of 48 patients with temporal and extra-temporal epilepsy surgery were studied. Forty patients had lesional surgery. All had at least 2 year postoperative follow-up. Results –
At 2 year follow-up, 25 patients (53%) were seizure free. Univariate analysis showed that APS (P = 0.048), using ≥six AEDs prior to surgery (P = 0.03), pathological postoperative EEG (P = 0.043) and female gender (P = 0.012) were associated with seizure recurrence. Conclusions –
Univariate analysis indicate that APS, a high number of AEDs used prior to surgery, and pathological postoperative EEG are possible predictors of seizure recurrence after epilepsy surgery. Only gender retained significance in the multivariate analysis.
Document Type: Research Article
Affiliations: 1: National Centre for Epilepsy, Rikshospitalet University Hospital, Oslo, Norway 2: Neurosurgical Department, Rikshospitalet University Hospital, Oslo, Norway 3: Department of Pediatrics, Ullevål University Hospital, Oslo, Norway 4: Division of Pathology, Rikshospitalet University Hospital, Oslo, Norway 5: Department of Laboratory Medicine/Pathology, Umeå University Hospital, Umeå, Sweden 6: Department of Neurodiagnostics, National Centre for Epilepsy, Division of Clinical Neuroscience, Rikshospitalet University Hospital, Oslo, Norway
Publication date: January 1, 2011