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Acute postoperative seizures after epilepsy surgery – a long-term outcome predictor?

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Alfstad KÅ, Lossius MI, Røste GK, Mowinckel P, Scheie D, Borota OC, Larsson PG, Nakken KO. Acute postoperative seizures after epilepsy surgery – a long-term outcome predictor?

Acta Neurol Scand: 2011: 123: 48–53.

© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. Objectives – 

The prognostic value of acute postoperative seizures (APS) after epilepsy surgery is much debated. This study evaluated APS, defined as seizures in the first week post-surgery, as a predictor of long-term seizure outcome, and investigated the utility of other potential outcome predictors. Materials and methods – 

Medical records of 48 patients with temporal and extra-temporal epilepsy surgery were studied. Forty patients had lesional surgery. All had at least 2 year postoperative follow-up. Results – 

At 2 year follow-up, 25 patients (53%) were seizure free. Univariate analysis showed that APS (P = 0.048), using ≥six AEDs prior to surgery (P = 0.03), pathological postoperative EEG (P = 0.043) and female gender (P = 0.012) were associated with seizure recurrence. Conclusions – 

Univariate analysis indicate that APS, a high number of AEDs used prior to surgery, and pathological postoperative EEG are possible predictors of seizure recurrence after epilepsy surgery. Only gender retained significance in the multivariate analysis.
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Keywords: epilepsy; postoperative seizures; seizure outcome; surgery

Document Type: Research Article

Affiliations: 1: National Centre for Epilepsy, Rikshospitalet University Hospital, Oslo, Norway 2: Neurosurgical Department, Rikshospitalet University Hospital, Oslo, Norway 3: Department of Pediatrics, Ullevål University Hospital, Oslo, Norway 4: Division of Pathology, Rikshospitalet University Hospital, Oslo, Norway 5: Department of Laboratory Medicine/Pathology, Umeå University Hospital, Umeå, Sweden 6: Department of Neurodiagnostics, National Centre for Epilepsy, Division of Clinical Neuroscience, Rikshospitalet University Hospital, Oslo, Norway

Publication date: 2011-01-01

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