Skip to main content

The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severity

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Hegland O, Kurz MW, Munk PS, Larsen JP. The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severity.

Acta Neurol Scand: 2010: 121: 11–15.

© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives – 

To examine the effect of early statin treatment on progression of arteriosclerosis in internal carotid arteries (ICA); to compare the progression of arteriosclerosis in ICA of patients treated with a statin to the progression seen in drug-naïve patients. Patients and methods – 

We performed repetitive Doppler scans of 363 carotid arteries with ICA stenosis ≥40% in 254 patients over time. Information on statin therapy and other risk factors for stroke were correlated with the annual change in degree of ICA stenosis. Results – 

In statin-treated patients, 19% of ICA stenosis showed a progression while 74% showed a regression of stenosis. In statin-naïve patients, 63% of stenotic arteries showed a progression, while a reduction could be observed in 28%. Decrease of ICA stenosis was most accentuated in patients with a mild stenosis and was independent of serum cholesterol levels. Conclusion – 

Treatment with statins already in early stages of ICA stenosis might delay the progression and even reverse the degree of stenosis.

Keywords: arteriosclerosis; carotid stenosis; statin; stroke

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0404.2009.01280.x

Affiliations: Department of Neurology, Stavanger University Hospital, Stavanger, Norway

Publication date: 2010-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more