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The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severity

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Hegland O, Kurz MW, Munk PS, Larsen JP. The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severity.

Acta Neurol Scand: 2010: 121: 11–15.

© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives – 

To examine the effect of early statin treatment on progression of arteriosclerosis in internal carotid arteries (ICA); to compare the progression of arteriosclerosis in ICA of patients treated with a statin to the progression seen in drug-naïve patients. Patients and methods – 

We performed repetitive Doppler scans of 363 carotid arteries with ICA stenosis ≥40% in 254 patients over time. Information on statin therapy and other risk factors for stroke were correlated with the annual change in degree of ICA stenosis. Results – 

In statin-treated patients, 19% of ICA stenosis showed a progression while 74% showed a regression of stenosis. In statin-naïve patients, 63% of stenotic arteries showed a progression, while a reduction could be observed in 28%. Decrease of ICA stenosis was most accentuated in patients with a mild stenosis and was independent of serum cholesterol levels. Conclusion – 

Treatment with statins already in early stages of ICA stenosis might delay the progression and even reverse the degree of stenosis.
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Keywords: arteriosclerosis; carotid stenosis; statin; stroke

Document Type: Research Article

Affiliations: Department of Neurology, Stavanger University Hospital, Stavanger, Norway

Publication date: 01 January 2010

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