The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severity
Abstract:Hegland O, Kurz MW, Munk PS, Larsen JP. The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severity.
Acta Neurol Scand: 2010: 121: 11–15.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives –
To examine the effect of early statin treatment on progression of arteriosclerosis in internal carotid arteries (ICA); to compare the progression of arteriosclerosis in ICA of patients treated with a statin to the progression seen in drug-naïve patients. Patients and methods –
We performed repetitive Doppler scans of 363 carotid arteries with ICA stenosis ≥40% in 254 patients over time. Information on statin therapy and other risk factors for stroke were correlated with the annual change in degree of ICA stenosis. Results –
In statin-treated patients, 19% of ICA stenosis showed a progression while 74% showed a regression of stenosis. In statin-naïve patients, 63% of stenotic arteries showed a progression, while a reduction could be observed in 28%. Decrease of ICA stenosis was most accentuated in patients with a mild stenosis and was independent of serum cholesterol levels. Conclusion –
Treatment with statins already in early stages of ICA stenosis might delay the progression and even reverse the degree of stenosis.